DCTN4 Polyclonal Antibody

Background:
Dynactin is a multisubunit complex and a required cofactor for most, or all, of the cellular processes powered by the microtubule-based motor cytoplasmic dynein . Dynactin contains a short actin-related protein 1 (Arp1) filament with capZ at the barbed end and p62 at the pointed end . The p62 subunit is an integral component of 20 S dynactin with a highly conserved cysteine-rich motif that interacts directly with Arp1. Dynactin p62 has a punctate cytoplasmic distribution as well as centrosomal distribution typical of dynactin . In addition, Dynactin p62 is distributed in the nucleus at very high expression levels . Due to the structural composition of dynactin, the p62 subunit is implicated in Arp1 pointed-end binding and in linking dynein and dynactin to the cortical cytoskeleton.

Research Area: Cancer, Signal Transduction

Synonyms:
DCTN 4, Dctn4, DCTN4, Dynactin 4 (p62), Dynactin 4, Dynactin p62 subunit, Dynactin subunit 4, Dynactin subunit p62, Dynactin4, p62

Immunogen: Recombinant protein of human DCTN4

Swissprot: Q9UJW0
Gene Accession: BC026323

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.6 mg/mL
Dilution: IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-12239/sc-12241/sc-25730