DCX antibody (clone 1G12), anti-human
€435.00
In stock
SKU
AC-AT1727a
Catalog Number: AC-AT1727a
Size: 100 µg
Isotype: mouse IgG1 kappa
Applications: WB, IF
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Size: 100 µg
Isotype: mouse IgG1 kappa
Applications: WB, IF
Request Information AC-AT1727a">Request Information
Background:
This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia (double cortex syndrome) in females and lissencephaly (smooth brain syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene.
Other Names:
Neuronal migration protein doublecortin, Doublin, Lissencephalin-X, Lis-X, DCX, DBCN, LISX
Antigen Type:
Recombinant Protein
Gene Name: DCX
Gene ID: 1641
NCBI Accession: NP_000546.2;NP_835364.1;NP_835365.1;NP_835366.1
Primary Accession: O43602
Other Accession: BC027925
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia (double cortex syndrome) in females and lissencephaly (smooth brain syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene.
Other Names:
Neuronal migration protein doublecortin, Doublin, Lissencephalin-X, Lis-X, DCX, DBCN, LISX
Antigen Type:
Recombinant Protein
Gene Name: DCX
Gene ID: 1641
NCBI Accession: NP_000546.2;NP_835364.1;NP_835365.1;NP_835366.1
Primary Accession: O43602
Other Accession: BC027925
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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