DCX polyclonal (S128), anti-human
€0.00
In stock
SKU
AC-AP2768a
Catalog Number: AC-AP2768a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB15193
Applications: WB, IHC-P
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB15193
Applications: WB, IHC-P
Datasheet
Request Information
Background:
In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. DCX is a cytoplasmic protein which appears to direct neuronal migration by regulating the organization and stability of microtubules. It contains two doublecortin domains, which bind microtubules. In addition, this protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in the gene encoding DCX are a cause of X-linked lissencephaly.
Other Names:
Neuronal migration protein doublecortin, Doublin, Lissencephalin-X, Lis-X, DCX, DBCN, LISX
Target/Specificity:
This DCX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 107-137 amino acids from human DCX.
Antigen Region:
107-137
Antigen Type: Synthetic Peptide
Gene Name: DCX
Gene ID: 1641
Primary Accession: O43602
NCBI Accession: NP_000546.2;NP_835364.1;NP_835365.1;NP_835366.1
Other Accession: Q9ESI7; O88809
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. DCX is a cytoplasmic protein which appears to direct neuronal migration by regulating the organization and stability of microtubules. It contains two doublecortin domains, which bind microtubules. In addition, this protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in the gene encoding DCX are a cause of X-linked lissencephaly.
Other Names:
Neuronal migration protein doublecortin, Doublin, Lissencephalin-X, Lis-X, DCX, DBCN, LISX
Target/Specificity:
This DCX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 107-137 amino acids from human DCX.
Antigen Region:
107-137
Antigen Type: Synthetic Peptide
Gene Name: DCX
Gene ID: 1641
Primary Accession: O43602
NCBI Accession: NP_000546.2;NP_835364.1;NP_835365.1;NP_835366.1
Other Accession: Q9ESI7; O88809
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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