DDB2 polyclonal, anti-human

Quantity: 100 µg

Background:
DNA damage-binding protein 2 is a protein that in humans is encoded by the DDB2 gene. This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. And this subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. Two transcript variants encoding different isoforms have been found for this gene.

Description:
Rabbit IgG polyclonal antibody for DNA damage-binding protein 2 (DDB2) detection. Tested with WB in Human.

Synonyms:
damage-specific DNA binding protein 2 antibody, Damage-specific DNA-binding protein 2 antibody, DDB p48 subunit antibody, Ddb2 antibody, DDB2_HUMAN antibody, DDBb antibody, DNA damage-binding protein 2 antibody, UV-damaged DNA-binding protein 2 antibody, UV-DDB 2 antibody, Xeroderma pigmentosum group E protei antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human DDB2 recombinant protein (Position: M1-T115). Human DDB2 shares 58.3% amino acid (aa) sequence identity with mouse DDB2.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.