DDIT3 polyclonal, anti-human, mouse, rat

Background:
GADD 153 has been described as a growth arrest and DNA damage-inducible gene that encodes a C/EBP-related nuclear protein. This protein has also been designated C/EBP-homologous protein (CHOP-10). GADD 153 expression is induced by a variety of cellular stresses, inducing nutrient deprivation and metabolic perturbations. GADD 153 functions to block cells in G1 to S phase in cell cycle progression and acts by dimerizing with other C/EBP proteins to direct GADD 153 dimers away from "classical" C/EBP binding sites, recognizing instead unique "nonclassical" sites. Thus GADD 153 acts as a negative modulator of C/EBP-like proteins in certain terminally differentiated cells, similar to the regulatory function of Id on the activity of Myo D and Myo D-related proteins involved in the development of muscle cells.

Alternative Name:
CHOP, CHOP-10, DDIT-3, C/EBP homologous protein, C/EBP Homology Protein, C/EBP zeta, C/EBP-homologous protein 10, C/EBP-homologous protein, CCAAT/enhancer binding protein homologous protein, CEBPZ, CHOP 10, CHOP, CHOP-10, CHOP10, DDIT 3, DDIT-3, Ddit3, DDIT3, DNA Damage Inducible Transcript 3, DNA damage-inducible transcript 3 protein, GADD 153, GADD153, Growth Arrest and DNA Damage Inducible Protein 153, Growth arrest and DNA damage inducible protein GADD153, Growth arrest and DNA damage-inducible protein GADD153, MGC4154,

Application Dilution:
WB:1:1,000
FC:1:50-1:100
IHC:1:50-1:200

Specificity: DDIT3 polyclonal antibody detects endogenous levels of DDIT3 protein.

Immunogen:
recombinant protein

MW: 25 kDa

Swiss-Prot: P35638(Human) P35639(Mouse) Q62857(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.