DDIT4 polyclonal, anti-human, mouse, rat

Background:
REDD-1, also designated DNA-damage-inducible transcript 4, dig2 or RTP801, is thought to function in the regulation of reactive oxygen species (ROS). REDD-1 expression has also been linked to apoptosis, Ab toxicity and the pathogenesis of ischemic diseases. As an HIF-1-responsive gene, REDD-1 exhibits strong hypoxia-dependent upregulation in ischemic cells of neuronal origin. In response to stress due to DNA damage and glucocorticoid treatment, REDD-1 is upregulated at the transcriptional level. REDD-1 negatively regulates the mammalian target of Rapamycin (mTOR), a serine/threonine kinase often referred to as FRAP. It is crucial in the coupling of extra- and intracellular cues to FRAP regulation. The absence of REDD-1 is associated with the development of retinopathy, a major cause of blindness.

Alternative Name:
REDD-1, DDIT4, REDD1, RTP801, DDIT4, DDIT4, Dig2, DNA damage inducible transcript 4, DNA damage inducible transcript 4 protein, DNA damage-inducible transcript 4 protein, FLJ20500, HIF 1 responsive protein RTP801, HIF 1 responsive RTP801, HIF-1 responsive protein RTP801, Protein regulated in development and DNA damage response 1, REDD-1, REDD1, RTP801,

Application Dilution:
WB:1:500
ICC:1:50-1:100
IHC:1:50-1:200
FC:1:50-1:100

Specificity: DDIT4 polyclonal antibody detects endogenous levels of DDIT4 protein.

Immunogen:
Peptide.

MW: 25 kDa (Predicted band size）

Swiss-Prot: Q9NX09(Human) Q9D3F7(Mouse) Q8VHZ9(Rat)

Purification & Purity:
Peptide affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.