DDX58 polyclonal, anti-human
€388.00
In stock
SKU
BS6819
Background:
Retinoic acid inducible gene I (RIG-I) is a 925 amino acid, interferon-inducible cellular DExD/H box RNA helicase that activates type I interferon (IFN), an important effector of the innate immune system that is sensitive to these dsRNA viruses. dsRNA is normally present in very low quantities in cells, so when a virus is present, the elevated levels of dsRNA act as a sign telling RIG-I to activate the production of IFN. RIG-I does this by using its helicase domain to bind to viral dsRNA, thus transmitting the activation signal for IFN through IkB kinase-related kinases and inducing IFN expression.
Alternative Name:
Probable ATP-dependent RNA helicase DDX58, DEAD box protein 58, RIG-I-like receptor 1, RLR-1, RLR1, Retinoic acid-inducible gene 1 protein, RIG-1, RIG1, Retinoic acid-inducible gene I protein, RIG-I, RIGI,
Application Dilution: WB: 1:500~1:2000, IHC/IF: 1:50~1:200
Specificity: DDX58 polyclonal antibody detects endogenous levels of DDX58 protein.
Immunogen:
Recombinant full length Human DDX58.
MW: ~ 107 kDa
Swis Prot.: O95786
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Retinoic acid inducible gene I (RIG-I) is a 925 amino acid, interferon-inducible cellular DExD/H box RNA helicase that activates type I interferon (IFN), an important effector of the innate immune system that is sensitive to these dsRNA viruses. dsRNA is normally present in very low quantities in cells, so when a virus is present, the elevated levels of dsRNA act as a sign telling RIG-I to activate the production of IFN. RIG-I does this by using its helicase domain to bind to viral dsRNA, thus transmitting the activation signal for IFN through IkB kinase-related kinases and inducing IFN expression.
Alternative Name:
Probable ATP-dependent RNA helicase DDX58, DEAD box protein 58, RIG-I-like receptor 1, RLR-1, RLR1, Retinoic acid-inducible gene 1 protein, RIG-1, RIG1, Retinoic acid-inducible gene I protein, RIG-I, RIGI,
Application Dilution: WB: 1:500~1:2000, IHC/IF: 1:50~1:200
Specificity: DDX58 polyclonal antibody detects endogenous levels of DDX58 protein.
Immunogen:
Recombinant full length Human DDX58.
MW: ~ 107 kDa
Swis Prot.: O95786
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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