DEFB121 polyclonal, anti-human
€388.00
In stock
SKU
BS6249
Background:
β-defensins (also designated BDs, or hBDs in human) are small cationic peptides with broad-spectrum antimicrobial activity against a variety of enveloped viruses, fungi and bacteria. Produced in mucosal epithelia and neutrophils of several species, β-defensins are developmentally regulated. The family of β-defensin proteins share a common defensin-motif that is characterized by multiple cysteine residues and a highly conserved tertiary structure. Besides playing a significant role in host immune defense, many β-defensins also are involved in sperm maturation and capacitation. β-defensin 121 is a 76 amino acid secreted protein that most likely contains a signal peptide sequence that requires cleavage by proteolytic enzymes in order to become biologically active. While expressed at low levels in testis, β-defensin 121 is abundantly expressed in epididymal caput and corpus and, unlike other β-defensins, it does not appear to be regulated by androgens.
Alternative Name:
beta 121, Beta-defensin 121, Beta-defensin 21, DB121, DEFB-21, DEFB121, Defensin, defensin, beta 121, defensin, beta 21, ESC42RELC,
Application Dilution: IHC: 1:50 - 1:100
Specificity: DEFB121 polyclonal antibody detects endogenous levels of DEFB1211 protein.
Immunogen:
Recombinant full length Human DEFB121.
MW: ~ 8 kDa
Swis Prot.: Q5J5C9
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
β-defensins (also designated BDs, or hBDs in human) are small cationic peptides with broad-spectrum antimicrobial activity against a variety of enveloped viruses, fungi and bacteria. Produced in mucosal epithelia and neutrophils of several species, β-defensins are developmentally regulated. The family of β-defensin proteins share a common defensin-motif that is characterized by multiple cysteine residues and a highly conserved tertiary structure. Besides playing a significant role in host immune defense, many β-defensins also are involved in sperm maturation and capacitation. β-defensin 121 is a 76 amino acid secreted protein that most likely contains a signal peptide sequence that requires cleavage by proteolytic enzymes in order to become biologically active. While expressed at low levels in testis, β-defensin 121 is abundantly expressed in epididymal caput and corpus and, unlike other β-defensins, it does not appear to be regulated by androgens.
Alternative Name:
beta 121, Beta-defensin 121, Beta-defensin 21, DB121, DEFB-21, DEFB121, Defensin, defensin, beta 121, defensin, beta 21, ESC42RELC,
Application Dilution: IHC: 1:50 - 1:100
Specificity: DEFB121 polyclonal antibody detects endogenous levels of DEFB1211 protein.
Immunogen:
Recombinant full length Human DEFB121.
MW: ~ 8 kDa
Swis Prot.: Q5J5C9
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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