DEK polyclonal, anti-human

Background:
The mammalian nuclear phosphoprotein DEK is implicated in multiple cellular processes, including transcriptional regulation, mRNA processing, and chromatin remodeling, and is associated with a number of clinical autoimmune and neoplastic conditions. DEK, an abundant chromatin-associated protein, changes the topology of DNA in chromatin in vitro. Although first identified in a fusion with the CAN/Nup214 nucleoporin protein in a specific subtype of acute myelogenous leukemia, DEK is also an autoantigen in patients with Pauciarticular onset juvenile rheumatoid arthritis. Furthermore, the last 65 amino acids of DEK can partially reverse the mutation-prone phenotype of cells from patients with ataxia-telangiectasia. The human DEK gene maps to chromosome 6p22.3.

Alternative Name:
DEK, D6S231E, Dek, DEK gene, DEK oncogene, DEK oncogene DNA binding, DEK, Protein DEK,

Application Dilution:
WB:1:500-1:1,000
IP:1:50-1:100

Specificity: DEK polyclonal antibody detects endogenous levels of DEK protein.

Immunogen:
Recombinant protein corresponding to C-terminal human DEK.

MW: 43 kDa

Swiss-Prot: P35659(Human)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.