DENND1B polyclonal, anti-human, mouse

Background:
Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery.

Synonyms: FAM31B, C1ORF18, C1orf218

Cellular Location: Cytoplasm

Immunogen:
Recombinant protein of human DENND1B

Gene Symbol: DENND1B

Gene ID: 163486

Swiss prot: Q6P3S1

Calculated MW: 86 kDa

Recommended dilution:
WB 1:500-2000

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.