DENND1B Polyclonal Antibody

Background:
Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery.

Research Area: Cell Biology

Synonyms:
C1ORF18, C1orf218 , Chromosome 1 open reading frame 218, Connecdenn 2, DEN1B, DENN domain containing protein 1B, DENN domain-containing protein 1B, DENN MADD domain containing 1B, DENND1B, DKFZp547O0715, FAM31B , Family with sequence similarity 31 member B, FLJ20054, FLJ21179 , FLJ33888, MGC103810, MGC27044, Protein FAM31B, RP11 53I24.2

Immunogen: Fusion protein of human DENND1B

Swissprot: Q6P3S1
Gene Accession: BC063877

Calculated MW: 86 kDa
Observed MW: Refer to figures

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.54 mg/mL
Dilution: WB 1:500-1:2000, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.