DENND1B polyclonal (N-term), anti-human
€0.00
In stock
SKU
AC-AP10381A
Catalog Number: AC-AP10381A
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB28056
Applications: FC, IHC-P, WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB28056
Applications: FC, IHC-P, WB
Datasheet
Request Information
Background:
Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).
Other Names:
DENN domain-containing protein 1B, Connecdenn 2, Protein FAM31B, DENND1B, C1orf218, FAM31B
Target/Specificity:
This DENND1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-68 amino acids from the N-terminal region of human DENND1B.
Antigen Region:
39-68
Antigen Type: Synthetic Peptide
Gene Name: DENND1B (HGNC:28404)
Gene ID: 163486
Primary Accession: Q6P3S1
NCBI Accession: NP_001182144.1;NP_001182145.1;NP_659414.2
Other Accession: Q3U1T9; NP_001182144.1; NP_001182145.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).
Other Names:
DENN domain-containing protein 1B, Connecdenn 2, Protein FAM31B, DENND1B, C1orf218, FAM31B
Target/Specificity:
This DENND1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-68 amino acids from the N-terminal region of human DENND1B.
Antigen Region:
39-68
Antigen Type: Synthetic Peptide
Gene Name: DENND1B (HGNC:28404)
Gene ID: 163486
Primary Accession: Q6P3S1
NCBI Accession: NP_001182144.1;NP_001182145.1;NP_659414.2
Other Accession: Q3U1T9; NP_001182144.1; NP_001182145.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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