DERL1 polyclonal (C-term), anti-human, mouse
€0.00
In stock
SKU
AC-AP8745b
Catalog Number: AC-AP8745b
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB22770
Applications: FC, IHC-P, WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB22770
Applications: FC, IHC-P, WB
Datasheet
Request Information
Background:
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. DERL1 may act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. It may mediate the interaction between VCP and the degradation substrate. In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein.
Other Names:
Derlin-1, Degradation in endoplasmic reticulum protein 1, DERtrin-1, Der1-like protein 1, DERL1, DER1
Target/Specificity:
This DERL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 224-251 amino acids from the C-terminal region of human DERL1.
Antigen Region:
224-251
Antigen Type: Synthetic Peptide
Gene Name: DERL1 (HGNC:28454)
Gene ID: 79139
Primary Accession: Q9BUN8
NCBI Accession: NP_001128143.1;NP_077271.1
Other Accession: Q99J56; Q71SS4
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. DERL1 may act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. It may mediate the interaction between VCP and the degradation substrate. In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein.
Other Names:
Derlin-1, Degradation in endoplasmic reticulum protein 1, DERtrin-1, Der1-like protein 1, DERL1, DER1
Target/Specificity:
This DERL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 224-251 amino acids from the C-terminal region of human DERL1.
Antigen Region:
224-251
Antigen Type: Synthetic Peptide
Gene Name: DERL1 (HGNC:28454)
Gene ID: 79139
Primary Accession: Q9BUN8
NCBI Accession: NP_001128143.1;NP_077271.1
Other Accession: Q99J56; Q71SS4
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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