Desmin (clone DES/1711), anti-human, mouse, rat, chicken, hamster
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In stock
SKU
AC-AH13161
Catalog Number: AC-AH13161
Size: 20 µg, 100 µg
Isotype: Mouse
Clone Name: DES/1711
Applications: WB, IHC-P, IF, FC
Datasheet
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Size: 20 µg, 100 µg
Isotype: Mouse
Clone Name: DES/1711
Applications: WB, IHC-P, IF, FC
Datasheet
Request Information
Background:
Cytoskeletal intermediate filaments (IFs) constitute a diverse group of proteins that are expressed in a highly tissue-specific manner. IFs are constructed from two-chain α-helical coiled-coil molecules arranged on an imperfect helical lattice, and have been widely used as markers for distinguishing individual cell types within a tissue and identifying the origins of metastatic tumors. Vimentin is an IF general marker of cells originating in the mesenchyme. Vimentin and Desmin, a related class III IF, are both expressed during skeletal muscle development. Desmin, a 469 amino acid protein found near the Z line in sarcomeres, is expressed more frequently in adult differentiated state tissues. Anti-desmin detects cells of normal smooth, skeletal, and cardiac muscles. Antibody reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin.
Other Names:
CMD1I; CSM1; CSM2; DES; Intermediate filament protein
Antigen Type:
Recombinant protein
Gene Name: DES
Gene ID: 1674
Primary Accession: P17661
Other Accession: 594952
Cytoskeletal intermediate filaments (IFs) constitute a diverse group of proteins that are expressed in a highly tissue-specific manner. IFs are constructed from two-chain α-helical coiled-coil molecules arranged on an imperfect helical lattice, and have been widely used as markers for distinguishing individual cell types within a tissue and identifying the origins of metastatic tumors. Vimentin is an IF general marker of cells originating in the mesenchyme. Vimentin and Desmin, a related class III IF, are both expressed during skeletal muscle development. Desmin, a 469 amino acid protein found near the Z line in sarcomeres, is expressed more frequently in adult differentiated state tissues. Anti-desmin detects cells of normal smooth, skeletal, and cardiac muscles. Antibody reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin.
Other Names:
CMD1I; CSM1; CSM2; DES; Intermediate filament protein
Antigen Type:
Recombinant protein
Gene Name: DES
Gene ID: 1674
Primary Accession: P17661
Other Accession: 594952
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