Desmin (clone RD301), anti-human, mouse, rat, canine, chicken, hamster, rabbit, swine, zebrafish
€564.00
In stock
SKU
ARP-21-5063
Catalog Number: 21-5063
Size: 100 µg
Isotype: Mouse IgG2b
Size: 100 µg
Isotype: Mouse IgG2b
Background:
Desmin is a 53 kDa intermediate filament protein that exhibits a high degree of tissue specificity, its expression being predominantly confined to all types of muscle cells (cardiac, skeletal and smooth muscle). Regulation of desmin expression is stage and tissue-specific, since it is induced during terminal development of, for example, skeletal muscle cell differentiation. In skeletal en cardiac muscle cells desmin is localized in the Z-disk region and at the intercalated disk. The expression pattern of desmin in smooth muscle is much more heterogenous. Coexpression of vimentin and desmin has been observed in tumors derived from muscle tissue, i.e. rhabdomyosarcomas and leiomyosarcomas. Furthermore, during myocard dysfunction dramatic changes in the distribution of desmin have been observed.
Clone: RD301
Isotype: Mouse IgG2b
Source: RD301 is a Mouse monoclonal IgG2b antibody derived by fusion of SP2/0-Ag14 Mouse myeloma cells with spleen cells from a Mouse immunized with a cytoskeletal desmin extract of Chicken gizzard.
Reactivity: canine, chicken, hamster, human, mouse, rabbit, rat, swine, zebrafish
Specificity: RD301 reacts exclusively with desmin, which is expressed in smooth and striated muscle cells and their tumors e.g. rhabdomyosarcoma and leiomyosarcoma.
Form: Each vial contains 100ul purified monoclonal antibody in PBS containing 0.09% sodium azide.
Applications: Immunohistochemistry (frozen), Western blotting
Storage: Store at 4C, or in small aliquots at -20C.
Desmin is a 53 kDa intermediate filament protein that exhibits a high degree of tissue specificity, its expression being predominantly confined to all types of muscle cells (cardiac, skeletal and smooth muscle). Regulation of desmin expression is stage and tissue-specific, since it is induced during terminal development of, for example, skeletal muscle cell differentiation. In skeletal en cardiac muscle cells desmin is localized in the Z-disk region and at the intercalated disk. The expression pattern of desmin in smooth muscle is much more heterogenous. Coexpression of vimentin and desmin has been observed in tumors derived from muscle tissue, i.e. rhabdomyosarcomas and leiomyosarcomas. Furthermore, during myocard dysfunction dramatic changes in the distribution of desmin have been observed.
Clone: RD301
Isotype: Mouse IgG2b
Source: RD301 is a Mouse monoclonal IgG2b antibody derived by fusion of SP2/0-Ag14 Mouse myeloma cells with spleen cells from a Mouse immunized with a cytoskeletal desmin extract of Chicken gizzard.
Reactivity: canine, chicken, hamster, human, mouse, rabbit, rat, swine, zebrafish
Specificity: RD301 reacts exclusively with desmin, which is expressed in smooth and striated muscle cells and their tumors e.g. rhabdomyosarcoma and leiomyosarcoma.
Form: Each vial contains 100ul purified monoclonal antibody in PBS containing 0.09% sodium azide.
Applications: Immunohistochemistry (frozen), Western blotting
Storage: Store at 4C, or in small aliquots at -20C.
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