Desmin K5 polyclonal, anti-bovine, chicken, caprine, hamster, human, mouse, rat, zebrafish

Quantity: 250 µl

Background:
Desmin is a 53 kDa intermediate filament protein and exhibits a high degree of tissue specificity, its expression being predominantly confined to all types of muscle cells (cardiac, skeletal and smooth muscle). Regulation of desmin expression is stage and tissue-specific, since it is induced during terminal development and muscle cell differentiation. In skeletal en cardiac muscle cells desmin is localized in the Z-disk region and at the intercalated disk. The expression pattern of desmin in smooth muscle is much more heterogenous. Coexpression of desmin and vimentin has been observed in tumors derived from muscle tissue, i.e. rhabdomyosarcomas and leiomyosarcomas. Furthermore, during myocard dysfunction dramatic changes in the distribution of desmin have been observed.

Isotype: Rabbit Polyclonal

Source: K5 is a Rabbit Serum directed anti Chicken gizzard muscle desmin. Desmin was purified from a crude tissue prepaRation by prepaRative gel electrophoresis as described in reference 1.

Form: Each vial contains 250 ul Rabbit polyclonal anti-serum containing 0.09% sodium azide.

Reactivity: bovine, chicken, Caprine, hamster, human, mouse, rat, Zebrafish

Applications: Immunohistochemistry (frozen), Immunohistochemistry (paraffin), Western blotting

Storage: Store at 4C, or in small aliquots at -20C.