Desmin polyclonal, anti-human, most mammals, birds

Quantity: 100 µl

Background:
This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies.

Synonyms:
CSM1, CSM2, LGMD2R

Isotype: Rabbit Polyclonal

Immunogen:
Purified desmin from chicken gizzard

Form: Serum containing 0.1% sodium azide

Specificity:
It reacts with the 53kDa desmin protein and does not crossreact with other intermediate filament proteins.

Reactivity: human, most mammals, birds

Applications: Immunoblotting, Immunohistochemistry, suitable for frozen and Paraffin sections. (no proteolytic treatment required)

Working DIlution: 1:25 to 1:50 (IHC, ABC method); 1:50 to 1:250 (Western blotting, ECL)

Positive Control:
Skeletal and smooth muscle tissue, myosarcoma

Storage: 2-8C for immediate use, or at -20C (aliquot)

References:
- Garcia Martinez, V. et al.(1986), Anat. Embryol 174: 83-89