Desmin polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
DES, also called desmin, is a protein that in humans is encoded by the DES gene, and this gene is mapped to 2q35. DES is the muscle-specific member of the intermediate filament (IF) protein family. It is one of the earliest myogenic markers, both in heart and somites, and is expressed in satellite stem cells and replicating myoblasts. DES is very important in muscle cell architecture and structure since it connects many components of the cytoplasm. It may be also play an important role in mitochondria function. What’s more, DES provides attachments between the terminal Z disc and membrane-associated proteins to form a force-transmitting system that parallels the thin filaments at myotendinous junctions.

Description:
Rabbit IgG polyclonal antibody for Desmin (DES) detection. Tested with WB, IHC-P, IHC-F in Human, Mouse, Rat.

Synonyms:
CMD1I antibody, CSM1 antibody, CSM2 antibody, DES antibody, DESM_HUMAN antibody, Desmin antibody, FLJ12025 antibody, FLJ39719 antibody, FLJ41013 antibody, FLJ41793 antibody, Intermediate filament protein antibody, OTTHUMP00000064865 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human Desmin recombinant protein (Position: M1-T304). Human Desmin shares 97% amino acid (aa) sequences identity with both mouse and rat Desmin.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB, IHC-P, IHC-F

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.