Desmocollin 2 polyclonal, anti-human, bovine

Quantity: 100 µl

Background:
The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11. Alternative splicing results in two transcript variants encoding distinct isoforms.

Synonyms:
DSC2, DG2, DSC3, CDHF2, ARVD11, DGII/III

Isotype: Rabbit Polyclonal

Immunogen:
Extracellular part of human Desmocollin 2 (recombinant)

Form: Stabilized Serum

Specificity:
All desmosome-possessing cell types, including epithelia, myocardiac cells and lymph nodes and neoplasia derived therefrom.

Reactivity: human, bovine

Applications: Western blot technique, Immunohistochemistry on frozen and paraffin (P) sections, Cytological material

Working DIlution: 1:20 for Immunohistochemistry; 1:10 for Paraffin-embedded tissue; 1:400 for Western blotting (ECL)

Storage: 2-8C for immediate use, or at -20C (aliquot)

References:
- Nuber UA. et al. (1995) Eur. J. Cell Biol. 66: 69-74 2.
- Moll I, et al. (1999) Arch. Dermatol. Res. 291: 437-466