Desmocollin 2 polyclonal, anti-human, bovine

Quantity: 25 µl

Background:
The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11. Alternative splicing results in two transcript variants encoding distinct isoforms.

Synonyms:
DSC2, DG2, DSC3, CDHF2, ARVD11, DGII/III

Isotype: Guinea pig Polyclonal

Immunogen:
Extracellular part of human Desmocollin 2 (recombinant)

Form: Stabilized Serum

Specificity:
Desmocollin 2a and 2b (splice forms; MW 78,535, corresponding to 712 amino acids). All desmosome-possessing cell types, including epithelia, myocardiac cells and lymph nodes neoplasia derived thereform.

Reactivity: human, bovine

Applications: Suitable for Immunohistochemistry on frozen and paraffin sections, Immunoblotting (Western), Cytological material

Working DIlution: 1:100 for immunohistochemistry (frozen sections); 1: 50 for paraffin sections; 1:2000 for Western blotting

Storage: 2-8C

References:
- Nuber, U.A., et al. (1995) Eur. J. Cell Biol.66: 69-742.
- Kurzen, H. et al. (1998) Differentiation 63: 295-304