DFFB polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS60830
Background:
The Ced/ICE or caspase family of cysteine proteases plays a pivotol role in mediating apoptosis through the proteolysis of specific targets. Among the targets are poly(ADP-ribose) polymerase (PARP), Gelsolin, ICAD (inhibitor of CAD, also designated DFF-45) and the nuclear lamins. CAD (caspase-activated deoxyribonuclease), also designated CPAN (caspase-activated nuclease) and DFF40, is a DNase that is responsible for DNA degradation during apoptosis. Caspase-3 acts to dissociate CAD from ICAD, allowing CAD to enter the nucleus and degrade DNA.
Alternative Name:
DNA fragmentation factor subunit beta (EC:3.-.-.-), Caspase-activated deoxyribonuclease, CAD, Caspase-activated DNase, CPAN, DNA fragmentation factor 40 kDa subunit, DFF-40, DFFB
Application Dilution: WB: 1:500~1:1000
Specificity: DFFB polyclonal antibody detects endogenous levels of DFFB protein.
Immunogen:
A synthetic peptide corresponding to residues in Human DFFB.
MW: ~ 39 kDa
Swis Prot.: O76075
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The Ced/ICE or caspase family of cysteine proteases plays a pivotol role in mediating apoptosis through the proteolysis of specific targets. Among the targets are poly(ADP-ribose) polymerase (PARP), Gelsolin, ICAD (inhibitor of CAD, also designated DFF-45) and the nuclear lamins. CAD (caspase-activated deoxyribonuclease), also designated CPAN (caspase-activated nuclease) and DFF40, is a DNase that is responsible for DNA degradation during apoptosis. Caspase-3 acts to dissociate CAD from ICAD, allowing CAD to enter the nucleus and degrade DNA.
Alternative Name:
DNA fragmentation factor subunit beta (EC:3.-.-.-), Caspase-activated deoxyribonuclease, CAD, Caspase-activated DNase, CPAN, DNA fragmentation factor 40 kDa subunit, DFF-40, DFFB
Application Dilution: WB: 1:500~1:1000
Specificity: DFFB polyclonal antibody detects endogenous levels of DFFB protein.
Immunogen:
A synthetic peptide corresponding to residues in Human DFFB.
MW: ~ 39 kDa
Swis Prot.: O76075
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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