DHCR24 Antibody (N-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP2840a
Background:
DHCR24 is a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. This protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of its gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.
Other Names:
Delta(24)-sterol reductase, 24-dehydrocholesterol reductase, 3-beta-hydroxysterol delta-24-reductase, Diminuto/dwarf1 homolog, Seladin-1, DHCR24, KIAA0018
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP2840a was selected from the N-term region of human DHCR24. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: DHCR24
Gene ID: 1718
Primary Accession: Q15392
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
DHCR24 is a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. This protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of its gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.
Other Names:
Delta(24)-sterol reductase, 24-dehydrocholesterol reductase, 3-beta-hydroxysterol delta-24-reductase, Diminuto/dwarf1 homolog, Seladin-1, DHCR24, KIAA0018
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP2840a was selected from the N-term region of human DHCR24. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: DHCR24
Gene ID: 1718
Primary Accession: Q15392
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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