DHCR24 Polyclonal Antibody

Background:
This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.

Research Area: Cancer, Cell Biology, Cardiovascular, Metabolism, Neuroscience

Synonyms:
24 dehydrocholesterol reductase, 24-dehydrocholesterol reductase, 3 beta hydroxysterol delta 24 reductase, 3-beta-hydroxysterol delta-24-reductase, DCE, Delta(24)-sterol reductase, Desmosterol to cholesterol enzyme, DHC24, Dhcr24, Diminuto dwarf1 homolog, Diminuto/dwarf1 homolog, KIAA0018, Nbla03646, Seladin-1, SELADIN1, Selective AD indicator 1, Selective Alzheimer's Disease Indicator 1

Immunogen: Recombinant protein of human DHCR24

Swissprot: Q15392
Gene Accession: BC004375

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.7 mg/mL
Dilution: IHC 1:30-1:150

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-48475/sc-48476/sc-48477