DHCR24 Polyclonal Antibody

Background:
This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.

Research Area: Cancer, Cell Biology, Cardiovascular, Metabolism, Neuroscience

Synonyms:
DHCR24, DCE, Nbla03646, SELADIN1, seladin-1

Immunogen: Recombinant fusion protein of human DHCR24 (NP_055577.1).

Swissprot: Q15392
Gene ID: 1718

Calculated MW: 54 kDa/60 kDa
Observed MW: 55 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.