DIABLO Polyclonal Antibody

Background:
This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and it moderates the caspase inhibition of IAPs. Multiple polyadenylation sites have been found for this gene. Four alternatively spliced transcript variants have been described for this gene, with two of them encoding different isoforms and the other two probably not encoding a protein. Ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes. Isoform 3 is ubiquitously expressed.

Research Area: Cancer, Cell Biology, Metabolism

Synonyms:
0610041G12Rik, DBLOH, DBOH, DFNA64, diablo, Diablo homolog (Drosophila), Diablo homolog, Diablo homolog mitochondrial, Diablo IAP binding mitochondrial protein, Diablo like protein, DIABLO S, Direct IAP binding protein with low pI, Direct IAP-binding protein with low pI, FLJ10537, FLJ25049, mitochondrial, Mitochondrial Smac protein, Second mitochondria derived activator of caspase, Second mitochondria-derived activator of caspase, SMAC 3, Smac, Smac protein, SMAC3

Immunogen: Recombinant protein of human DIABLO

Swissprot: Q9NR28
Gene Accession: BC011909

Calculated MW: 27 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.3 mg/mL
Dilution: WB 1:1000-1:5000, IHC 1:100-1:300

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-12683/sc-12684/sc-22766