Dicer polyclonal, anti-human

Quantity: 100 µg

Background:
Dicer(DICER1), also known as endoribonuclease Dicer or helicase with RNase motif, is an enzyme that in humans is encoded by the DICER1 gene. It is mapped to 14q32.13. The DICER1 gene, a member of the ribonuclease III (RNaseIII) family, is involved in the generation of microRNAs (miRNAs), which modulate gene expression at the posttranscriptional level. DICER1 possesses an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus DICER, also known as helicase-MOI, is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. In addition, DICER1 is required for formation of the RNA induced silencing complex (RISC). It also cleaves double-stranded RNA to produce short interfering RNAs (siRNAs) which target the selective destruction of complementary RNAs.

Description:
Rabbit IgG polyclonal antibody for Endoribonuclease Dicer (DICER1) detection. Tested with WB, IHC-P in Human.

Synonyms:
DCR antibody, DCR1 antibody, Dcr1 homolog (Drosophila) antibody, Dicer 1 antibody, Dicer 1 ribonuclease type III antibody, Dicer antibody, DICER_HUMAN antibody, Dicer1 antibody, Double-strand-specific ribonuclease antibody, Endoribonuclease Dicer antibody, Helicase moi antibody, Helicase with RNAse motif antibody, HERNA antibody, KIAA0928 antibody, MNG1 antibody, RMSE2 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human Dicer recombinant protein (Position: M1-N195). Human Dicer shares 94% amino acid (aa) sequence identity with mouse Dicer.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.