DICER1 polyclonal, anti-human, mouse
€305.00
In stock
SKU
BS61872
Background:
The mammalian Dicer is a type III RNase-related protein with orthologs in yeast, Drosophila and Arabidopsis. Dicer contains an RNA-helicase motif, including a DEXH box in its amino-terminus and an RNase motif in the carboxyterminus. The gene encoding human Dicer maps to chromosome 14q32.13. Dicer is expressed in brain, heart, liver, lung, pancreas, kidney and placenta, and functions in the RNA interference pathway. Dicer cleaves short hairpin RNA precursors of approximately 70 bp into 21-23 bp dsRNAs that selectively target the destruction of homologous RNAs. Dicer localizes to the cytoplasm of mammalian cells. Specifically, it co-localizes with calreticulin in the endoplasmic reticulum. Although the cleavage of RNA by Dicer is ATP-independent, the product release necessary for the rapid turnover of this enzyme may be attributed to ATP. Immunoprecipitation studies indicate Dicer forms a complex with the PIWI domain of eIF2C translation initiation factors
Alternative Name:
Endoribonuclease Dicer, Helicase with RNase motif, Helicase MOI, DICER1, DICER, HERNA, KIAA0928
Application Dilution: WB: 1:500~1:1000
Specificity: DICER1 pAb detects endogenous levels of DICER1 protein.
Immunogen:
Synthetic peptide, corresponding Human DICER1.
MW: ~ 260 kDa
Swis Prot.: Q9UPY3
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The mammalian Dicer is a type III RNase-related protein with orthologs in yeast, Drosophila and Arabidopsis. Dicer contains an RNA-helicase motif, including a DEXH box in its amino-terminus and an RNase motif in the carboxyterminus. The gene encoding human Dicer maps to chromosome 14q32.13. Dicer is expressed in brain, heart, liver, lung, pancreas, kidney and placenta, and functions in the RNA interference pathway. Dicer cleaves short hairpin RNA precursors of approximately 70 bp into 21-23 bp dsRNAs that selectively target the destruction of homologous RNAs. Dicer localizes to the cytoplasm of mammalian cells. Specifically, it co-localizes with calreticulin in the endoplasmic reticulum. Although the cleavage of RNA by Dicer is ATP-independent, the product release necessary for the rapid turnover of this enzyme may be attributed to ATP. Immunoprecipitation studies indicate Dicer forms a complex with the PIWI domain of eIF2C translation initiation factors
Alternative Name:
Endoribonuclease Dicer, Helicase with RNase motif, Helicase MOI, DICER1, DICER, HERNA, KIAA0928
Application Dilution: WB: 1:500~1:1000
Specificity: DICER1 pAb detects endogenous levels of DICER1 protein.
Immunogen:
Synthetic peptide, corresponding Human DICER1.
MW: ~ 260 kDa
Swis Prot.: Q9UPY3
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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