DISC1 (C-term) polyclonal, anti-human, mouse, rat

Protein Family: Cytoskeleton Proteins

Pathway and Disease: Development and Behavior, Nervous and Sensory Systems, Signaling Molecules and Interaction

Description:
Disrupted in Schizophrenia 1 protein (DISC1) interacts with a variety of cytoskeletal proteins such as tubulin alpha, ACTN2 and ATF4. DISC1 is involved in neurite outgrowth and cortical development through interaction with other proteins. Genetic variation in DISC1 is associated with susceptibility to schizophrenia.

Alternate Names: Disrupted in Schizophrenia 1 protein, DISC1

Application Notes: E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500

Accession No.: Q9NRI5

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human DISC1.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.

Product Citations:
[1] Pinero-Martos E et al. 2016. Hum Mol Genet. 25(19): 4157-4169. PMID 27466199.