DISC1 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS7737
Background:
The “Disrupted In Schizophrenia” gene locus DISC is associated with patients afflicted with schizophrenia as a result of chromosomal translocations. DISC-1 encodes a large protein predicted to contain a globular N-terminal domain and a helical C-terminal domain, both of which have the potential to form interactions with other proteins. DISC-1 interacts with proteins involved in the centrosome and cytoskeletal system, including MIPT3, MAP1A and nudel; proteins which localize receptors to membranes, including a-actinin-2 and spectrin b IV; and proteins which transduce signals from membrane receptors, including ATF-4 and ATF-5. Therefore, DISC-1 is thought to be involved in intracellular transport, neurite architecture and/or neuronal migration, all of which are thought to be pathogenic in the schizophrenic brain. DISC-1 localizes to the nucleus, whereas mutant DISC-1 localization occurs mainly in the cytoplasm.
Alternative Name:
C1orf136, DISC1, DISC1_HUMAN, Disrupted in schizophrenia 1, Disrupted in schizophrenia 1 protein, KIAA0457, RP4-730B13.1, SCZD9,
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200
Specificity: DISC1 polyclonal antibody detects endogenous levels of DISC1 protein.
Immunogen:
Recombinant full length Human DISC1.
MW: ~ 100 kDa
Swis Prot.: Q9NRI5
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The “Disrupted In Schizophrenia” gene locus DISC is associated with patients afflicted with schizophrenia as a result of chromosomal translocations. DISC-1 encodes a large protein predicted to contain a globular N-terminal domain and a helical C-terminal domain, both of which have the potential to form interactions with other proteins. DISC-1 interacts with proteins involved in the centrosome and cytoskeletal system, including MIPT3, MAP1A and nudel; proteins which localize receptors to membranes, including a-actinin-2 and spectrin b IV; and proteins which transduce signals from membrane receptors, including ATF-4 and ATF-5. Therefore, DISC-1 is thought to be involved in intracellular transport, neurite architecture and/or neuronal migration, all of which are thought to be pathogenic in the schizophrenic brain. DISC-1 localizes to the nucleus, whereas mutant DISC-1 localization occurs mainly in the cytoplasm.
Alternative Name:
C1orf136, DISC1, DISC1_HUMAN, Disrupted in schizophrenia 1, Disrupted in schizophrenia 1 protein, KIAA0457, RP4-730B13.1, SCZD9,
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200
Specificity: DISC1 polyclonal antibody detects endogenous levels of DISC1 protein.
Immunogen:
Recombinant full length Human DISC1.
MW: ~ 100 kDa
Swis Prot.: Q9NRI5
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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