Dishevelled 3 polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS5705
Background:
Mammalian homologs of the Drosophila dishevelled (Dsh) gene have been identified, including Dvl-1, Dvl-2 and Dvl-3. The mammalian dishevelled proteins contain three homologous domains, two of which are unrelated to any other known protein. The third region is homologous to the discs-large homology domain of Drosophila discs-large-1, a tumor suppressor protein. Like their Drosophila counterpart, the dishevelled proteins are thought to be in-volved in embryogenesis. Overexpression of Dvl-1 has been shown to inhibit the phosphorylation of tau by GSK-3b. This finding may prove to be important in Alzheimer’s studies, which have shown that tau is hyperphosphorylated. In Drosophila, Dsh is a component of the frizzled signaling pathway. Both mammalian dishevelled and frizzled proteins are components of the Wnt signalling pathway.
Alternative Name:
Segment polarity protein dishevelled homolog DVL-3, Dishevelled-3, Dishevelled3, DSH homolog 3, DVL3, KIAA0208
Application Dilution: WB: 1:500~1:1000
Specificity: Dishevelled 3 polyclonal antibody detects endogenous levels of Dishevelled 3 protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 368-413 of Human Dishevelled 3.
MW: ~ 90 kDa
Swis Prot.: Q92997
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Mammalian homologs of the Drosophila dishevelled (Dsh) gene have been identified, including Dvl-1, Dvl-2 and Dvl-3. The mammalian dishevelled proteins contain three homologous domains, two of which are unrelated to any other known protein. The third region is homologous to the discs-large homology domain of Drosophila discs-large-1, a tumor suppressor protein. Like their Drosophila counterpart, the dishevelled proteins are thought to be in-volved in embryogenesis. Overexpression of Dvl-1 has been shown to inhibit the phosphorylation of tau by GSK-3b. This finding may prove to be important in Alzheimer’s studies, which have shown that tau is hyperphosphorylated. In Drosophila, Dsh is a component of the frizzled signaling pathway. Both mammalian dishevelled and frizzled proteins are components of the Wnt signalling pathway.
Alternative Name:
Segment polarity protein dishevelled homolog DVL-3, Dishevelled-3, Dishevelled3, DSH homolog 3, DVL3, KIAA0208
Application Dilution: WB: 1:500~1:1000
Specificity: Dishevelled 3 polyclonal antibody detects endogenous levels of Dishevelled 3 protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 368-413 of Human Dishevelled 3.
MW: ~ 90 kDa
Swis Prot.: Q92997
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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