DKC1 polyclonal, anti-human, mouse, rat

Background:
Isoform 1: Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. Isoform 3: Promotes cell to cell and cell to substratum adhesion, increases the cell proliferation rate and leads to cytokeratin hyper-expression (when overexpressed in HeLa cells).

Alternative Name:
NOLA4, CBF5, CBF5 homolog, Cbf5p homolog, DKC 1, DKC, Dkc1, DKC1, DKCX, Dyskeratosis congenita 1, Dyskeratosis congenita 1 dyskerin, Dyskerin, H/ACA ribonucleoprotein complex subunit 4, NAP 57, NAP57, NOLA 4, NOLA4, Nopp140 associated protein of 57 kDa, Nopp140-associated protein of 57 kDa, Nucleolar protein family A member 4, Nucleolar protein NAP57, snoRNP protein DKC1, XAP 101, XAP101,

Application Dilution:
WB:1:500-1:1,000
ICC:1:50-1:200
IHC:1:50-1:100

Specificity: DKC1 polyclonal antibody detects endogenous levels of DKC1 protein.

Immunogen:
Recombinant protein

MW: 57 kDa

Swiss-Prot: O60832(Human) Q9ESX5(Mouse) P40615(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.