DKC1 polyclonal, anti-human, mouse, rat

Background:
This gene functions in two distinct complexes. It plays an active role in telomerase stabilization and maintenance, as well as recognition of snoRNAs containing H/ACA sequences which provides stability during biogenesis and assembly into H/ACA small nucleolar RNA ribonucleoproteins (snoRNPs). This gene is highly conserved and widely expressed, and may play additional roles in nucleo-cytoplasmic shuttling, DNA damage response, and cell adhesion. Mutations have been associated with X-linked dyskeratosis congenita. Alternative splicing results in multiple transcript variants.

Synonyms: CBF5, DKC, DKCX, NAP57, NOLA4, XAP101

Cellular Location: Cajal body Cytoplasm Nucleus nucleolus

Immunogen:
Recombinant protein of human DKC1

Gene Symbol: DKC1

Gene ID: 1736

Swiss prot: O60832

Calculated MW: 58kDa

Recommended dilution:
WB 1:500-2000, IHC 1:50-200, IF 1:50-200,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.