DKK-1 polyclonal, anti-human, mouse, rat
€455.00
In stock
SKU
AC-ABO10781
Catalog Number: AC-ABO10781
Size: 100 µg
Isotype: Rabbit IgG
Applications: WB
Datasheet
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Size: 100 µg
Isotype: Rabbit IgG
Applications: WB
Datasheet
Request Information
Description: Rabbit IgG polyclonal antibody for Dickkopf-related protein 1(DKK1) detection. Tested with WB in Human;Mouse;Rat.Protein Name: Dickkopf-related protein 1(Dickkopf-1/Dkk-1/hDkk-1)
Protein Function:
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. .
Other Names: Dickkopf-related protein 1, Dickkopf-1, Dkk-1, hDkk-1, SK, DKK1
Subcellular Localization: Secreted.
Tissue Specificity: Placenta.
Gene ID: 22943
Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human DKK1(68-83aa YPGGNKYQTIDNYQPY), different from the related mouse and rat sequences by two amino acids.
Calculated MW: 28672
Purification: Immunogen affinity purified.
Format: Lyophilized
Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Concentration (mg/ml): Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.
Protein Function:
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. .
Other Names: Dickkopf-related protein 1, Dickkopf-1, Dkk-1, hDkk-1, SK, DKK1
Subcellular Localization: Secreted.
Tissue Specificity: Placenta.
Gene ID: 22943
Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human DKK1(68-83aa YPGGNKYQTIDNYQPY), different from the related mouse and rat sequences by two amino acids.
Calculated MW: 28672
Purification: Immunogen affinity purified.
Format: Lyophilized
Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Concentration (mg/ml): Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.
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