DKK1 polyclonal, anti-human, mouse, rat
€0.00
In stock
SKU
AC-AP21147a
Catalog Number: AC-AP21147a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB52126
Applications: IHC-P-Leica, IF, WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB52126
Applications: IHC-P-Leica, IF, WB
Datasheet
Request Information
Background:
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Other Names:
Dickkopf-related protein 1, Dickkopf-1, Dkk-1, hDkk-1, SK, DKK1
Target/Specificity:
This DKK1 antibody is generated from a rabbit immunized with a recombinant protein of human DKK1.
Antigen Region:
1-266
Gene Name: DKK1
Gene ID: 22943
Primary Accession: O94907
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Other Names:
Dickkopf-related protein 1, Dickkopf-1, Dkk-1, hDkk-1, SK, DKK1
Target/Specificity:
This DKK1 antibody is generated from a rabbit immunized with a recombinant protein of human DKK1.
Antigen Region:
1-266
Gene Name: DKK1
Gene ID: 22943
Primary Accession: O94907
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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