DKK1 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
DKK1, Dickkopf-related protein 1, is a protein that in humans is encoded by the DKK1 gene. This gene encodes a protein that is a member of the dickkopf family. By genomic sequence analysis, determined that the DKK1 gene contains 4 exons. The DKK1 gene is mapped to 10q11.2 using FISH. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.

Description:
Rabbit IgG polyclonal antibody for Dickkopf-related protein 1 (DKK1) detection. Tested with WB in Human, Mouse, Rat.

Synonyms:
Dickkopf 1 antibody, Dickkopf 1 homolog antibody, Dickkopf 1 like antibody, Dickkopf homolog 1 antibody, Dickkopf like protein 1 antibody, Dickkopf related protein 1 antibody, Dickkopf-1 antibody, Dickkopf-related protein 1 antibody, DKK 1 antibody, Dkk-1 antibody, Dkk1 antibody, DKK1_HUMAN antibody, hDkk 1 antibody, hDkk-1 antibody, hDkk1 antibody, SK antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminus of human DKK1(68-83aa YPGGNKYQTIDNYQPY), different from the related mouse and rat sequences by two amino acids.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.