DLD Polyclonal Antibody

Background:
This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In homodimeric form, the encoded protein functions as a dehydrogenase and is found in several multi-enzyme complexes that regulate energy metabolism. However, as a monomer, this protein can function as a protease. Mutations in this gene have been identified in patients with E3-deficient maple syrup urine disease and lipoamide dehydrogenase deficiency. Alternative splicing results in multiple transcript variants.

Research Area: Cancer, Metabolism, Signal Transduction

Synonyms:
DLD, DLDD, DLDH, E3, GCSL, LAD, PHE3

Immunogen: Recombinant fusion protein of human DLD (NP_000099.2).

Swissprot: P09622
Gene ID: 1738

Calculated MW: 43 kDa/49 kDa/54 kDa
Observed MW: 54 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:200"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.