DLL1 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
DLL1(DELTA-LIKE 1) also known as DL1 or DELTA1, is a protein that in humans is encoded by the DLL1 gene. DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication. Using FISH, Gray et al.(1999) mapped the DLL1 gene to chromosome 6q27, near a locus for type I diabetes. Functional analysis by Han et al.(2000) suggested that a soluble fusion protein containing the DSL domain of DLL1 and its adjacent 50 N-terminal amino acids increased the viability of hemopoietic cells but inhibited cell death. Jaleco et al.(2001) used a cell coculture assay to show that DLL1 blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor. In contrast, JAG1 did not disturb either B-cell or T-cell/NK-cell development. Galceran et al. found that mouse Lef1 bound multiple sites in the Dll1 promoter in vitro and in vivo, and mutation of the Lef1 sites impaired expression of a reporter transgene in the presomitic mesoderm of embryonic mice.

Description:
Rabbit IgG polyclonal antibody for Delta-like protein 1 (DLL1) detection. Tested with WB in Human, Mouse, Rat.

Synonyms:
Delta(Drosophila) like 1 antibody, Delta antibody, Delta like 1(Drosophila) antibody, Delta like 1 antibody, Delta like 1 protein antibody, Delta like protein 1 antibody, Delta like protein 1 precursor antibody, Delta, Drosophila, homolog of 1 antibody, Delta-like protein 1 [Precursor] antibody, Delta-like protein 1 antibody, Delta1 antibody, DL1 antibody, DLL 1 antibody, Dll1 antibody, DLL1_HUMAN antibody, Drosophila Delta homolog 1 antibody, H-Delta-1 antibody, OTTHUMP00000017690 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminus of human DLL1(168-184aa RTDLKYSYRFVCDEHYY), different from the related rat and mouse sequences by one amino acid.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human.
Predicted to work with: mouse, rat.

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.