Claudin-1 polyclonal, anti-human, mouse, rat
€470.00
In stock
SKU
AC-AP69125
Catalog Number: AC-AP51165
Size: 100 µl
Host: Rabbit
Applications: WB, IP, ICC, IHC-P, E
Datasheet
Request Information
Size: 100 µl
Host: Rabbit
Applications: WB, IP, ICC, IHC-P, E
Datasheet
Request Information
Background:
Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (PubMed:23407391).
Other Names:
CLDN1; CLD1; SEMP1; Claudin-1; Senescence-associated epithelial membrane protein
Antigen Type: synthetic peptide
Antigen Type: CLDN1
Gene ID: 9076
Primary Accession: O95832
Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (PubMed:23407391).
Other Names:
CLDN1; CLD1; SEMP1; Claudin-1; Senescence-associated epithelial membrane protein
Antigen Type: synthetic peptide
Antigen Type: CLDN1
Gene ID: 9076
Primary Accession: O95832
| Is Featured? | No |
|---|
Write Your Own Review