DMAP1 Polyclonal Antibody

Background:
This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described.

Research Area: Cancer, Epigenetics and Nuclear Signaling

Synonyms:
DMAP1, DNMAP1, DNMTAP1, EAF2, MEAF2, SWC4

Immunogen: Recombinant fusion protein of human DMAP1 (NP_061973.1).

Swissprot: Q9NPF5
Gene ID: 55929

Calculated MW: 52 kDa
Observed MW: 60 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:1000-1:4000"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.