DMP1 Antibody (N-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP18965a
Background:
Dentin matrix acidic phosphoprotein is an extracellularmatrix protein and a member of the small integrin binding ligandN-linked glycoprotein family. This protein, which is critical forproper mineralization of bone and dentin, is present in diversecells of bone and tooth tissues. The protein contains a largenumber of acidic domains, multiple phosphorylation sites, afunctional arg-gly-asp cell attachment sequence, and a DNA bindingdomain. In undifferentiated osteoblasts it is primarily a nuclearprotein that regulates the expression of osteoblast-specific genes.During osteoblast maturation the protein becomes phosphorylated andis exported to the extracellular matrix, where it orchestratesmineralized matrix formation. Mutations in the gene are known tocause autosomal recessive hypophosphatemia, a disease thatmanifests as rickets and osteomalacia. The gene structure isconserved in mammals. Two transcript variants encoding differentisoforms have been described for this gene.
Other Names:
Dentin matrix acidic phosphoprotein 1, DMP-1, Dentin matrix protein 1, DMP1
Gene Name: DMP1
Gene ID: 1758
Primary Accession: Q13316
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Dentin matrix acidic phosphoprotein is an extracellularmatrix protein and a member of the small integrin binding ligandN-linked glycoprotein family. This protein, which is critical forproper mineralization of bone and dentin, is present in diversecells of bone and tooth tissues. The protein contains a largenumber of acidic domains, multiple phosphorylation sites, afunctional arg-gly-asp cell attachment sequence, and a DNA bindingdomain. In undifferentiated osteoblasts it is primarily a nuclearprotein that regulates the expression of osteoblast-specific genes.During osteoblast maturation the protein becomes phosphorylated andis exported to the extracellular matrix, where it orchestratesmineralized matrix formation. Mutations in the gene are known tocause autosomal recessive hypophosphatemia, a disease thatmanifests as rickets and osteomalacia. The gene structure isconserved in mammals. Two transcript variants encoding differentisoforms have been described for this gene.
Other Names:
Dentin matrix acidic phosphoprotein 1, DMP-1, Dentin matrix protein 1, DMP1
Gene Name: DMP1
Gene ID: 1758
Primary Accession: Q13316
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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