DMRT3 Polyclonal Antibody

Background:
The DMRT (doublesex and mab-3 related transcription factor) genes encode a large family of transcription factors that are related to the Drosophila doublesex proteins. Expressed primarily in the gonads, DMRT proteins contain cysteine-rich DNA-binding motifs and are thought to play an important role in sexual development. DMRT3 (doublesex and mab-3 related transcription factor 3), also known as DMRTA3, is a 472 amino acid protein that contains one DM DNA-binding domain and belongs to the DMRT family. Localized to the nucleus, DMRT3 is expressed specifically in testis and is thought to regulate transcriptional events during early sexual development. The gene encoding DMRT3 maps to human chromosome 9, which houses over 900 genes and comprises nearly 4% of the human genome. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, and Familial dysautonomia, are both associated with chromosome 9. Notably, chromosome 9 encompasses the largest interferon family gene cluster.

Research Area: Cancer, Metabolism, Developmental Biology

Synonyms:
DMRT 3, DMRT like family A3, dmrt3, DMRT3, DMRTA3, Doublesex and mab 3 related transcription factor 3, Doublesex- and mab-3-related transcription factor 3, MGC142144, Testis specific protein

Immunogen: Recombinant protein of human DMRT3

Swissprot: Q9NQL9
Gene Accession: BC113584

Calculated MW: 51 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.4 mg/mL
Dilution: WB 1:500-1:2000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-82581/sc-82580/sc-82579