DMTF1 Antibody (C-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP17665b
Background:
This gene encodes a transcription factor that contains acyclin D-binding domain, three central Myb-like repeats, and twoflanking acidic transactivation domains at the N- and C-termini.The encoded protein is induced by the oncogenic Ras signalingpathway and functions as a tumor suppressor by activating thetranscription of ARF and thus the ARF-p53 pathway to arrest cellgrowth or induce apoptosis. It also activates the transcription ofaminopeptidase N and may play a role in hematopoietic celldifferentiation. The transcriptional activity of this protein isregulated by binding of D-cyclins. This gene is hemizygouslydeleted in approximately 40% of human non-small-cell lung cancerand is a potential prognostic and gene-therapy target fornon-small-cell lung cancer. Multiple transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq].
Other Names:
Cyclin-D-binding Myb-like transcription factor 1, hDMTF1, Cyclin-D-interacting Myb-like protein 1, hDMP1, DMTF1, DMP1
Gene Name: DMTF1
Gene ID: 9988
Primary Accession: Q9Y222
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
This gene encodes a transcription factor that contains acyclin D-binding domain, three central Myb-like repeats, and twoflanking acidic transactivation domains at the N- and C-termini.The encoded protein is induced by the oncogenic Ras signalingpathway and functions as a tumor suppressor by activating thetranscription of ARF and thus the ARF-p53 pathway to arrest cellgrowth or induce apoptosis. It also activates the transcription ofaminopeptidase N and may play a role in hematopoietic celldifferentiation. The transcriptional activity of this protein isregulated by binding of D-cyclins. This gene is hemizygouslydeleted in approximately 40% of human non-small-cell lung cancerand is a potential prognostic and gene-therapy target fornon-small-cell lung cancer. Multiple transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq].
Other Names:
Cyclin-D-binding Myb-like transcription factor 1, hDMTF1, Cyclin-D-interacting Myb-like protein 1, hDMP1, DMTF1, DMP1
Gene Name: DMTF1
Gene ID: 9988
Primary Accession: Q9Y222
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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