DMTF1 antibody (clone 5C6), anti-human
€435.00
In stock
SKU
AC-AT1784a
Catalog Number: AC-AT1784a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IHC, IF
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Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IHC, IF
Request Information AC-AT1784a">Request Information
Background:
This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
Other Names:
Cyclin-D-binding Myb-like transcription factor 1, hDMTF1, Cyclin-D-interacting Myb-like protein 1, hDMP1, DMTF1, DMP1
Antigen Type:
Recombinant Protein
Gene Name: DMTF1
Gene ID: 9988
NCBI Accession: NP_001135798.1;NP_001135799.1;NP_066968.3
Primary Accession: Q9Y222
Other Accession: NM_021145
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
Other Names:
Cyclin-D-binding Myb-like transcription factor 1, hDMTF1, Cyclin-D-interacting Myb-like protein 1, hDMP1, DMTF1, DMP1
Antigen Type:
Recombinant Protein
Gene Name: DMTF1
Gene ID: 9988
NCBI Accession: NP_001135798.1;NP_001135799.1;NP_066968.3
Primary Accession: Q9Y222
Other Accession: NM_021145
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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