DMTF1 polyclonal (C-term), anti-human
€0.00
In stock
SKU
AC-AP17665b
Catalog Number: AC-AP17665b
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB37072
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB37072
Applications: WB
Datasheet
Request Information
Background:
This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Other Names:
Cyclin-D-binding Myb-like transcription factor 1, hDMTF1, Cyclin-D-interacting Myb-like protein 1, hDMP1, DMTF1, DMP1
Target/Specificity:
This DMTF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 588-616 amino acids from the C-terminal region of human DMTF1.
Antigen Region:
588-616
Antigen Type: Synthetic Peptide
Gene Name: DMTF1
Gene ID: 9988
Primary Accession: Q9Y222
NCBI Accession: NP_001135798.1;NP_001135799.1;NP_066968.3
Other Accession: Q66HG1; Q8CE22; NP_001135798.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Other Names:
Cyclin-D-binding Myb-like transcription factor 1, hDMTF1, Cyclin-D-interacting Myb-like protein 1, hDMP1, DMTF1, DMP1
Target/Specificity:
This DMTF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 588-616 amino acids from the C-terminal region of human DMTF1.
Antigen Region:
588-616
Antigen Type: Synthetic Peptide
Gene Name: DMTF1
Gene ID: 9988
Primary Accession: Q9Y222
NCBI Accession: NP_001135798.1;NP_001135799.1;NP_066968.3
Other Accession: Q66HG1; Q8CE22; NP_001135798.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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