DNA PKcs polyclonal, anti-human

Quantity: 100 µg

Background:
PRKDC(Protein Kinase DNA-Activated Catalytic Subunit), also called DNAPK, HYRC1, p350 or DNPK1, is an enzyme that in humans is encoded by the PRKDC gene. DNA-PKcs belongs to the phosphatidylinositol 3-kinase-related kinase protein family. Satoh et al.(1997) mapped the MCM4 gene to 8q11.2 by FISH. Based on the close proximity of the PRKDC and MCM4 genes, it was assumed that the PRKDC gene also maps to this location. Anderson and Lees-Miller(1992) noted that DNA-PK had been shown in vitro to phosphorylate several transcription factors, suggesting that it functions in cell homeostasis by modulating transcription. Daniel et al.(1999) demonstrated that the PRKDC protein participates in retroviral DNA integration, which is catalyzed by the viral protein integrase.

Description:
Rabbit IgG polyclonal antibody for DNA-dependent protein kinase catalytic subunit (PRKDC) detection. Tested with WB in Human.

Synonyms:
DNA dependent protein kinase catalytic subunit antibody, DNA PK catalytic subunit antibody, DNA-dependent protein kinase catalytic subunit antibody, DNA-PK catalytic subunit antibody, DNA-PKcs antibody, DNAPK antibody, DNAPK catalytic subunit antibody, DNPK 1 antibody, DNPK1 antibody, Hyper radiosensitivity of murine scid mutation, complementing 1 antibody, HYRC 1 antibody, HYRC antibody, HYRC1 antibody, p350 antibody, p460 antibody, PKRDC antibody, PRKDC antibody, PRKDC_HUMAN antibody, Protein Kinase DNA Activated Catalytic Polypeptide antibody, XRCC 7 antibody, XRCC7 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminus of human DNA PKcs(328-346aa AKNAEMHKNKLQYFMEQFY).

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.