DNASE1 polyclonal, anti-human, mouse
€295.00
In stock
SKU
K003399P
Catalog Number: K003399P
Size: 100 μl
Other size: 50 μl
Isotype: Rabbit IgG
Applications: WB, IF
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Questions? Contact us!
Size: 100 μl
Other size: 50 μl
Isotype: Rabbit IgG
Applications: WB, IF
Request Manual
Questions? Contact us!
Background:
This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
Synonyms: DNL1, DRNI
Cellular Location: Nucleus envelope Secreted
Immunogen:
Recombinant protein of human DNASE1
Gene Symbol: DNASE1
Gene ID: 1773
Swiss prot: P24855
Calculated MW: 31kDa
Recommended dilution:
WB 1:500-2000, IF 1:50-100,
Purity:
Affinity purification
Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at -20℃. Avoid freeze / thaw cycles.
This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
Synonyms: DNL1, DRNI
Cellular Location: Nucleus envelope Secreted
Immunogen:
Recombinant protein of human DNASE1
Gene Symbol: DNASE1
Gene ID: 1773
Swiss prot: P24855
Calculated MW: 31kDa
Recommended dilution:
WB 1:500-2000, IF 1:50-100,
Purity:
Affinity purification
Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at -20℃. Avoid freeze / thaw cycles.
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