DNASE1 polyclonal, anti-human, mouse, rat
€295.00
In stock
SKU
K008425P
Catalog Number: K008425P
Size: 100 μl
Other size: 50 μl
Isotype: Rabbit IgG
Applications: IHC
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Questions? Contact us!
Size: 100 μl
Other size: 50 μl
Isotype: Rabbit IgG
Applications: IHC
Request Manual
Questions? Contact us!
Background:
This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
Synonyms: DNL1, DRNI
Cellular Location: Secreted
Immunogen:
Recombinant protein of human DNASE1
Gene Symbol: DNASE1
Gene ID: 1773
Swiss prot: P24855
Calculated MW: 31kDa
Recommended dilution:
IHC 1:25-100
Purity:
Affinity purification
Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Storage:
Store at -20℃. Avoid freeze / thaw cycles.
This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
Synonyms: DNL1, DRNI
Cellular Location: Secreted
Immunogen:
Recombinant protein of human DNASE1
Gene Symbol: DNASE1
Gene ID: 1773
Swiss prot: P24855
Calculated MW: 31kDa
Recommended dilution:
IHC 1:25-100
Purity:
Affinity purification
Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Storage:
Store at -20℃. Avoid freeze / thaw cycles.
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