Dnmt3a monoclonal, anti-human
€0.00
In stock
SKU
AC-AM8628b
Catalog Number: AC-AM8628b
Size: 50 µl, 200 µl
Isotype: mouse IgG1,k
Clone Name: 1823CT281.43.36
Applications: WB
Datasheet
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Size: 50 µl, 200 µl
Isotype: mouse IgG1,k
Clone Name: 1823CT281.43.36
Applications: WB
Datasheet
Request Information
Background:
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.
Other Names:
DNA (cytosine-5)-methyltransferase 3A, Dnmt3a, 2.1.1.37, DNA methyltransferase HsaIIIA, DNA MTase HsaIIIA, M.HsaIIIA, DNMT3A
Target/Specificity:
This Dnmt3a antibody is generated from a mouse immunized with a recombinant protein of human Dnmt3a.
Antigen Type: Recombinant Protein
Gene Name: DNMT3A
Gene ID: 1788
Primary Accession: Q9Y6K1
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.
Other Names:
DNA (cytosine-5)-methyltransferase 3A, Dnmt3a, 2.1.1.37, DNA methyltransferase HsaIIIA, DNA MTase HsaIIIA, M.HsaIIIA, DNMT3A
Target/Specificity:
This Dnmt3a antibody is generated from a mouse immunized with a recombinant protein of human Dnmt3a.
Antigen Type: Recombinant Protein
Gene Name: DNMT3A
Gene ID: 1788
Primary Accession: Q9Y6K1
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