DNMT3A polyclonal, anti-human, mouse, rat

Background:
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms.

Synonyms: DNMT3A2, M.HsaIIIA

Cellular Location: Cytoplasm Nucleus

Immunogen:
Recombinant protein of human DNMT3A

Gene Symbol: DNMT3A

Gene ID: 1788

Swiss prot: Q9Y6K1

Calculated MW: 102kDa

Recommended dilution:
IHC 1:25-100

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.