DNMT3B Polyclonal Antibody

Background:
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.

Research Area: Cancer, Epigenetics and Nuclear Signaling

Synonyms:
DNMT3B, ICF, ICF1, M.HsaIIIB

Immunogen: Recombinant fusion protein of human DNMT3B (NP_008823.1).

Swissprot: Q9UBC3
Gene ID: 1789

Calculated MW: 77-95 kDa
Observed MW: 95 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:200-1:1000"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.